The is annoying, but it is rarely unfixable. In 90% of cases, simply updating your graphics driver or verifying the game files via Steam will solve the problem immediately.
If you have 4GB or less VRAM, the game may crash when loading high-res textures. Resident Evil 2 Fatal D3d Error-
On NVIDIA Optimus or AMD SmartShift systems, the game initializes on the integrated GPU (iGPU) but attempts exclusive fullscreen output via the discrete GPU (dGPU). The resulting adapter mismatch causes a D3D device state inconsistency. The is annoying, but it is rarely unfixable
Graphics drivers that are corrupt or not optimized for the game's current build. The is annoying