Drano Max Gel, Liquid-Plumr Full Clog Destroyer.
Sometimes a blockage is simply too solid for chemicals to dissolve (like a toy, a toothbrush, or a solidified grease "rock").
Live bacteria cultures (Bacillus) or enzymes (protease/lipase). How they work: These do not dissolve clogs instantly. Instead, they colonize your pipes and metabolize organic waste into water and carbon dioxide over 6 to 24 hours. Best for: Maintenance and slow drains, not solid blockages. Examples: Green Gobbler, Drano Prevention (enzymatic), Eco-Logic. Pros: Non-toxic, safe for septic systems, eco-friendly, and safe for all pipes including PVC. Cons: Will not clear a standing water clog; takes hours/days to work; bacteria die if hot water or chemical residue is present.
For those avoiding harsh chemicals or dealing with specific pipe types (like PVC), these alternatives are safer. Green Gobbler