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At the cellular level, temperatures above normal physiological ranges (37°C) induce stress responses. Heat shock proteins (HSPs) are rapidly expressed to protect cells from protein denaturation. Moderate hyperthermia (40–44°C) can enhance blood flow, increase oxygen delivery, and sensitize cells to radiation or chemotherapy. At higher temperatures (>45°C), direct protein coagulation and membrane disruption lead to cell death — a property exploited in tumor ablation.

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