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Wilms Tumor PPT New: A Modern Guide to Presentation, Diagnosis, and Treatment Updates Keywords: Wilms tumor ppt new, nephroblastoma slides, pediatric renal cancer, COG protocol, Umbrella protocol, pediatric oncology lecture Introduction: Why a “New” PPT on Wilms Tumor? Wilms tumor (nephroblastoma) is the most common primary malignant renal tumor in children, accounting for approximately 95% of all pediatric kidney cancers. While the survival rate has improved dramatically—from 30% in the 1930s to over 90% today—the landscape of management is constantly evolving. If you are searching for a “Wilms tumor ppt new,” you are likely preparing a lecture, a residency presentation, or an academic update. The keyword “new” is critical. Why? Because recent trials (AREN0534, AREN0533, and the ongoing Umbrella protocol) have shifted practice toward risk-stratified therapy , reduced radiation in low-risk groups, and introduced novel agents for recurrent disease. This article provides the content blueprint for a cutting-edge PPT.
Slide 1: Title Slide – The Modern Face of Wilms Tumor Suggested Title: Wilms Tumor 2025: From Imaging to Immunotherapy Subtitle: Updates from COG and SIOP-RTSG Protocols
Speaker Note: Begin with a case – a 3-year-old with an asymptomatic abdominal mass. This hooks the audience.
Slide 2: Epidemiology – Who, When, Why? wilms tumor ppt new
Incidence: 1 in 10,000 children; ~500 new cases/year in the US. Age peak: 3–4 years (median 3.5). Rare in neonates and adults. Bilateral: 5–7% of cases (synchronous or metachronous). Ethnicity: Slightly higher in African Americans; lower in East Asians. Associated syndromes (10%):
WAGR syndrome (WT1 deletion) Denys-Drash syndrome (WT1 mutation) Beckwith-Wiedemann syndrome (11p15 alteration)
New in 2025: Expanded genetic panels now identify cryptic 11p15 abnormalities in 15% of non-syndromic unilateral cases, influencing relapse risk. Wilms Tumor PPT New: A Modern Guide to
Slide 3: Pathology – Not All Wilms Are the Same Histologic Types (NWTS-5 classification): | Type | Favorable (FH) | Unfavorable (UH) | |------|----------------|------------------| | Triphasic (blastema, stroma, epithelium) | Anaplasia (focal or diffuse) | | Prognosis >90% survival | Requires intensified chemo | New Molecular Subgroups (2023–2024):
High-risk blastemal type (SIROP) → more aggressive. WT1-mutant vs. CTNNB1-mutant – different responses to doxorubicin.
PPT Tip: Use a Venn diagram showing overlapping features of triphasic histology. If you are searching for a “Wilms tumor
Slide 4: Clinical Presentation – The Classic Triad (But Often Incomplete)
Asymptomatic abdominal mass (80%) – parents notice during bathing. Hematuria (15–20%) – usually microscopic. Hypertension (25%) – due to renin secretion. Fever, malaise, weight loss – less common. Rare emergencies: Rupture (acute abdomen), bilateral ureteral obstruction.