, a single "ISO" file is actually a modern community creation designed for CD-ROM or virtual machine use. Primary Sources:
Do not use CD-RW. Many old CD-ROM drives cannot read rewritable discs.
: Hosts various community-uploaded versions, including a Bootable Installer ISO and combined Windows 3.11/MS-DOS 6.22 images.
It is classified as Abandonware . However, legally:
Search for "MS-DOS 6.22 ISO" on the Internet Archive to find community-contributed CD-ROM images that combine the three original setup disks into a single bootable disc. How to Create a Bootable MS-DOS 6.22 ISO
Once you have your MSDOS622.iso file, you have two paths: using a Virtual Machine (easiest) or real hardware (advanced).
: Offers pre-made DOS 6.22 boot disk images that can be used to create bootable USB drives or CDs. How to Create Your Own Bootable MS-DOS ISO